Established in 2015, the mission of the Lipedema Foundation (LF) is to define, diagnose, and develop treatments for lipedema. Lipedema is a chronic condition that occurs almost exclusively in women and manifests as symmetrical buildup of painful fat and swelling in the limbs, sparing the hands and feet. Limited understanding of disease biology, coupled with a lack of definitive diagnostic tools, has contributed to inadequate public, scientific and medical awareness of the disease. To address these challenges, LF has committed over $5 million toward building a new research field through training, proof-of-concept, and collaborative research awards. Our vision is to build a sustainable research field guided by transparency, collaboration, and community engagement.