The mission of the Simons Foundation is to advance the frontiers of research in the basic sciences and mathematics. In the life sciences, institutional and targeted grants support research in systems biology, human evolution and math in biology. The Simons Foundation Autism Research Initiative (SFARI) seeks to understand the causes of autism and thereby improve the diagnosis, treatment, and prevention of this and related developmental disorders. SFARI applications are solicited from individuals who will conduct bold, imaginative, rigorous research relevant to this spectrum of prevalent disorders. The Foundation supports the work of institutions and organizations that give many of the world’s best mathematicians and physicists the opportunity to work and interact in environments designed to enhance progress. Part of our mission is also to train students and educators in these disciplines, and to organize programs that introduce the wonders of these fields to children and to the general public.