Community Description

The Therapeutic Development Learning Community (formerly the Drug and Other Therapy Development [DOTD] Learning Community) helps HRA members identify strategies to accelerate discovery and development of drugs and other therapies in members’ areas of interest. It has two priorities:

1. Share examples of collaborations and/or consortia among academic and industry partners that are catalyzing effective drug discovery, drug development, or biomarker development.
2. Curate and share a “toolkit of toolkits” to enable member organizations to more easily identify and access existing and up-to-date resources relevant to DOTD working group goals.

This group focuses on issues specifically related to drug and other therapy development such as:

• Sharing documents such as MTAs, NDAs, research contracts, and multi-party contracts
• Working with big pharma – access to drugs on the shelf and a role for nonprofits in pharma drug development programs
• Metrics for drug development programs
• FDA issues: need for regulatory science; the need for EMEA-FDA harmonization
• Clinical research infrastructure to subsidize drug development costs
• Effect of nonprofit accounting standards on funding models
• Strategies for pricing of drugs developed with nonprofit funds

Featured Resources By Category

General Therapeutics Development Learning Community Resources

• Therapeutic Development Learning Community Re-Launch [May 30, 2024]
• Drug and Other Therapy Development Toolkit of Toolkits [Work in Progress]

Venture Philanthropy

• Venture Philanthropy: Is it for Me? [September 28, 2022]
• Venture Philanthropy: Is it for Everybody? [June 13, 2022]
• Venture Philanthropy: Untapped Potential or Unintended Consequences? Exploring Venture Capital Approaches in the Philanthropic Space [HRA Members Meeting, Spring 2020]

Facilitation of Bench-to-Bedside Research

• The Translational Research Pipeline: Strategies for Funders to Facilitate Bench-to-Bedside Research [Spring 2025 HRA Members Meeting, March 12, 2025]
• Unlocking Cures: Navigating the Therapeutics Frontier in Collaboration with the Federal Government [Fall 2024 HRA Members Meeting; October 1, 2024]
• Building Stronger Drug and Other Therapy Development Innovation Ecosystems – A Case Study [March 9, 2021]

Technical Considerations for Drug Discovery Projects

• Therapeutic Development Community Call: Intellectual Property in Drug Discovery and Development Projects [February 24, 2025]
• Gene Editing Workshop (FDA New Frontiers in Science Distinguished Lectureship Program)
• Protocols.io: How an open access platform to share the methods behind the data can enhance the impact of your grantees’ research and your funding [November 20, 2019]